Digital geometric definition of metallic scaffolds for potential applications in tissue engineering
DOI:
https://doi.org/10.17981/ingecuc.15.1.2019.02Keywords:
digital model, geometric definition, metallic scaffolds, tissue engineeringAbstract
Introduction: The design of porous structures used as scaffolds in tissue engineering, is directed towards the development of elements that promote bone consolidation processes, stabilizing tissue fragments in conventional biodegradable fixation devices.
Objective: To obtain a digital three-dimensional model for a cellular metal that resembles the cortical and trabecular bone morphology, with characteristics such as geometry, pore size, porosity and skin type coating, as well as providing a basis for the materialization of structures that improve bone regeneration and facilitate the control of the mechanical properties of the scaffold for the biological defects of its application.
Methodology: A parametric 3D modeling code is presented, by means of the definition of a uniform regular geometry with a suitable porosity and pore size, taking into account the essence of the cellular metals and complemented by a skin-like coating body that surrounds the three-dimensional model seeking to elevate the rigidity and mechanical strength of the scaffolding, in addition to making possible the machining of own geometries and allowing isolation and protection for the
cases in which it is required.
Results: The development of two digital models for cellular metals with complex morphological conditions was generated, allowing a good interrelation of geometric parameters for cell proliferation and a favorable response to structural stress in tissue engineering applications.
Conclusions: The designed model demonstrates the possibility of being applied to development of bone fixation alternatives, which decrease the inflammatory response, avoid secondary interventions and reduce the rejection rates of the elements currently used to treatment of musculoskeletal conditions.
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