Predictors of favorable response to implanted of ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus

Predictores de respuesta favorable al implante de derivación ventriculoperitoneal en pacientes con hidrocefalia idiopática de presión normal

Authors

  • Mario-Emiliano Ricciardi Neurology department, Fleni , Buenos Aires, Argentina
  • Ismael Calandri Cognitive Neurology, Neuropsychology and Neuropsychiatry department, Fleni, Buenos Aires, Argentina
  • Lucas Alessandro Neurology department, Fleni, Buenos Aires, Argentina
  • Mauricio Farez Center for Research on Neuroimmunological Diseases (CIEN), Fleni, Buenos Aires,
  • Juan Villalonga Neurosurgery department, Fleni, Buenos Aires, Argentina.
  • Martin Fausti Neurosurgery department, Fleni, Buenos Aires, Argentina.
  • Frida Herrmann Diagnostic imaging department, Fleni, Buenos Aires, Argentina.
  • Ricardo Allegri Cognitive Neurology, Neuropsychology and Neuropsychiatry department, Fleni, Buenos Aires, Argentina

DOI:

https://doi.org/10.17981/JACN.1.1.2020.10

Keywords:

Idiopathic normal pressure hydrocephalus, Ventriculoperitoneal shunt, Cognitive impairment, Gait disorder, Neurosurgery.

Abstract

Introduction: The indication of a ventriculoperitoneal shunt (VPS) is discussed in patients with idiopathic normal pressure hydrocephalus (iNPH), due to the heterogeneity of the response to treatment and the risks involved in neurosurgery. Objective: To search for clinical factors and complementary studies in order to determine predictors of a favorable response to the VPS placement in patients with iNPH. Methodology: A retrospective study of patients with probable iNPH (according to international guidelines) treated with VPS assisted in a neurological clinic from January 2014 to January 2017 was conducted. A univariate statistical
analysis of the variables considered as possible prognostic factors was performed. Results: 58 patients were included. Women presented 3.68 times more chances of improvement after the VPS (p=0.019). Good response to the gait test was associated with better response to the VPS (p=0.024). Conclusions: Female sex and good response to the gait test could be considered as predictors of a favorable response to the VPS placement in patients with iNPH. A prospective study is necessary to achieve a homogeneous diagnostic evaluation and a more extensive longitudinal follow-up to evaluate the clinical evolution in this group of patients.

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Published

2020-12-09

How to Cite

Ricciardi, M.-E., Calandri, I., Alessandro, L., Farez, M., Villalonga, J., Fausti, M., Herrmann, F., & Allegri, R. (2020). Predictors of favorable response to implanted of ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus: Predictores de respuesta favorable al implante de derivación ventriculoperitoneal en pacientes con hidrocefalia idiopática de presión normal. Journal of Applied Cognitive Neuroscience, 1(1), 81–86. https://doi.org/10.17981/JACN.1.1.2020.10

Issue

Vol. 1 No. 1 (2020): Journal of Applied Cognitive Neuroscience

Section

Original Article

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Copyright (c) 2020 Journal of Applied Cognitive Neuroscience

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